New, simple, cost effective, accurate and reproducible UV-spectrophotometric method was developed and validated for the estimation of nadifloxacin in bulk and pharmaceutical ingredient. Nadifloxacin was estimated at 237 nm in phosphate buffer (pH 6.8). Beer’s law was obeyed in the concentration range of 1–18 µg/ml (r2 = 0.9989) in phosphate buffer (pH 6.8). This method was tested and validated for various parameters according to ICH guidelines. The proposed method was successfully applied for the determination of nadifloxacin in bulk and pharmaceutical formulation. The results demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation < 2%). At the same time method being simple, cheap and less time consuming, can be suitably applied for the estimation of nadifloxacin in different dosage forms and dissolution studies.
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